Spoiler-Free Advice for RE:1 Remaster?

Tomorrow, I’m playing my very first RE game. I got the HD Remaster of the 2002 Resident Evil remake for my PS4, and I can’t wait to get into it!

To maximize immersion, I’m going to see how far I can progress without a walkthrough; but I’m still curious. What are some broad-stroke strategies that I can apply to improve my chances of success going in cold-turkey? Easy mistakes to avoid?

I’ve never played a Survival Horror game before, so I’d love to know what to expect from a mechanical standpoint; and how to approach it. That way I, hopefully, will limit the number of times I soft-lock my save files.