Any new home owners getting crushed by their mortgage payments?

Been in the market looking at houses and the monthly payments when I try to calculate it seem extremely daunting. Yet, these houses seem to fly off the market, going for way over asking. Does anyone feel like they've bitten off more than they could chew and regret buying? I'm not paying rent now, but I need to upsize in the near future. Just trying to get an idea of market sentiment.